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Blood microparticles are a component of immune modulation in red blood cell transfusion.

Authors
  • Pinheiro, Marion Klea1, 2, 3, 4
  • Tamagne, Marie1, 2, 3, 4
  • Elayeb, Rahma1, 2, 3, 4
  • Andrieu, Muriel5
  • Pirenne, France1, 2, 3, 4
  • Vingert, Benoît1, 2, 3, 4
  • 1 Etablissement Français du Sang, Ile-de-France, France. , (France)
  • 2 Institut Mondor de Recherche Biomédicale, lnserm U955, Equipe Pirenne, Créteil, France. , (France)
  • 3 Laboratory of Excellence GR-Ex, Paris, France. , (France)
  • 4 Université Paris-Est, Créteil, France. , (France)
  • 5 Institute Cochin, Cochin Cytometry and Immunobiology Facility, Paris, France. , (France)
Type
Published Article
Journal
European Journal of Immunology
Publisher
Wiley (John Wiley & Sons)
Publication Date
Aug 01, 2020
Volume
50
Issue
8
Pages
1237–1240
Identifiers
DOI: 10.1002/eji.201948481
PMID: 32379351
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Patients may display alloimmunization following transfusion. Microparticles (MPs) released into the blood are present in transfusion products. We show that MPs can modulate the immune system, CD4+ T-cell, and humoral responses, through their concentration, cellular origin and phenotype, and should therefore be considered to reduce the immune impact of transfusion. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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