Blood microparticles are a component of immune modulation in red blood cell transfusion.
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Authors
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Pinheiro, Marion Klea1, 2, 3, 4
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Tamagne, Marie1, 2, 3, 4
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Elayeb, Rahma1, 2, 3, 4
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Andrieu, Muriel5
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Pirenne, France1, 2, 3, 4
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Vingert, Benoît1, 2, 3, 4
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1
Etablissement Français du Sang, Ile-de-France, France.
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(France)
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2
Institut Mondor de Recherche Biomédicale, lnserm U955, Equipe Pirenne, Créteil, France.
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(France)
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3
Laboratory of Excellence GR-Ex, Paris, France.
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(France)
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4
Université Paris-Est, Créteil, France.
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(France)
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5
Institute Cochin, Cochin Cytometry and Immunobiology Facility, Paris, France.
,
(France)
- Type
- Published Article
- Journal
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European Journal of Immunology
- Publisher
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Wiley (John Wiley & Sons)
- Publication Date
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Aug 01, 2020
- Volume
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50
- Issue
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8
- Pages
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1237–1240
- Identifiers
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DOI: 10.1002/eji.201948481
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PMID: 32379351
- Source
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Medline
- Keywords
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- Language
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English
- License
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Unknown
Abstract
Patients may display alloimmunization following transfusion. Microparticles (MPs) released into the blood are present in transfusion products. We show that MPs can modulate the immune system, CD4+ T-cell, and humoral responses, through their concentration, cellular origin and phenotype, and should therefore be considered to reduce the immune impact of transfusion. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
This record was last updated on 12/04/2020 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at
https://www.ncbi.nlm.nih.gov/pubmed/32379351
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