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Blood genomic profiling: novel diagnostic and therapeutic strategies for stroke?

Authors
  • Baird, A E
Type
Published Article
Journal
Biochemical Society transactions
Publication Date
Dec 01, 2006
Volume
34
Issue
Pt 6
Pages
1313–1317
Identifiers
PMID: 17073810
Source
Medline
License
Unknown

Abstract

Findings from gene expression profiling studies are leading to new diagnostic and therapeutic strategies that can be applied in medical practice, especially in the field of oncology. Promising results of gene expression profiling of the peripheral blood in patients with ischaemic stroke have been obtained in recent pilot studies, demonstrating a partially reproducible gene signature of acute cerebral ischaemia. However, questions remain. Given that blood is at least in part a surrogate tissue for ischaemic stroke, the specificity of these signatures needs to be evaluated. Furthermore, it needs to be determined whether standardization of this methodology is required and whether clinical signatures can be identified that are improvements over the tools currently used in clinical practice. Clinically useful signatures would include those of haemorrhagic as well as ischaemic stroke, reclassification of stroke type and prognosis, and vascular disease risk. If these conditions are met, then it should be possible to develop cost-effective and rapid assays.

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