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Blood culture-PCR to optimise typhoid fever diagnosis after controlled human infection identifies frequent asymptomatic cases and evidence of primary bacteraemia.

Authors
  • Darton, Thomas C1
  • Zhou, Liqing2
  • Blohmke, Christoph J2
  • Jones, Claire2
  • Waddington, Claire S2
  • Baker, Stephen3
  • Pollard, Andrew J2
  • 1 Oxford Vaccine Group, Department of Paediatrics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom; The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam. Electronic address: [email protected] , (United Kingdom)
  • 2 Oxford Vaccine Group, Department of Paediatrics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom. , (United Kingdom)
  • 3 The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
The Journal of infection
Publication Date
Jan 24, 2017
Identifiers
DOI: 10.1016/j.jinf.2017.01.006
PMID: 28130144
Source
Medline
Keywords
License
Unknown

Abstract

Overall the culture-PCR assay performed well, identifying extra typhoid cases compared with routine blood culture alone. Despite limitations to widespread field-use, the benefits of increased diagnostic yield, reduced blood volume and faster turn-around-time, suggest that this assay could enhance laboratory typhoid diagnostics in research applications and high-incidence settings.

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