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Blood brain barrier modification and chemotherapy. Interventional neuroradiology in the treatment of malignant gliomas.

Authors
  • Heimberger, K
  • Samec, P
  • Binder, H
  • Podreka, I
  • Reisner, T
  • Deecke, L
  • Horaczek, A
  • Dittrich, C
  • Steger, G
  • Zimpfer, M
Type
Published Article
Journal
Acta radiologica. Supplementum
Publication Date
Jan 01, 1986
Volume
369
Pages
223–226
Identifiers
PMID: 2980457
Source
Medline
License
Unknown

Abstract

Postoperative interventional neuroradiology was performed in patients with malignant gliomas to increase target efficacy of chemotherapy. In 8 glioma patients the blood brain or blood tumor barrier was reversibly opened by intraarterial injection of hyperosmolar fluid (Mannitol 25%). One additional patient had primary lymphoma of the central nervous system. During barrier modification chemotherapeutic agents were applied intraarterially and intravenously. A total of 22 blood brain barrier modification procedures have been carried out until now, ranging from one to five per patient. A presently continuing tumor regression or tumor progression free intervals have been noted in 5 patients. Therapeutic effects are being evaluated from repeated computed tomography and single photon emission computed tomography examinations.

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