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Blood brain barrier modification and chemotherapy. Interventional neuroradiology in the treatment of malignant gliomas.

Authors
Type
Published Article
Journal
Acta radiologica. Supplementum
Publication Date
Volume
369
Pages
223–226
Identifiers
PMID: 2980457
Source
Medline

Abstract

Postoperative interventional neuroradiology was performed in patients with malignant gliomas to increase target efficacy of chemotherapy. In 8 glioma patients the blood brain or blood tumor barrier was reversibly opened by intraarterial injection of hyperosmolar fluid (Mannitol 25%). One additional patient had primary lymphoma of the central nervous system. During barrier modification chemotherapeutic agents were applied intraarterially and intravenously. A total of 22 blood brain barrier modification procedures have been carried out until now, ranging from one to five per patient. A presently continuing tumor regression or tumor progression free intervals have been noted in 5 patients. Therapeutic effects are being evaluated from repeated computed tomography and single photon emission computed tomography examinations.

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