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Blocking mast cell-mediated type I hypersensitivity in experimental allergic conjunctivitis by monocyte chemoattractant protein-1/CCR2.

Authors
  • Tominaga, Takeshi
  • Miyazaki, Dai
  • Sasaki, Shin-ichi
  • Mihara, Sachiko
  • Komatsu, Naoki
  • Yakura, Keiko
  • Inoue, Yoshitsugu
Type
Published Article
Journal
Investigative Ophthalmology & Visual Science
Publisher
Association for Research in Vision and Ophthalmology (ARVO)
Publication Date
Nov 01, 2009
Volume
50
Issue
11
Pages
5181–5188
Identifiers
DOI: 10.1167/iovs.09-3637
PMID: 19553621
Source
Medline
License
Unknown

Abstract

Stimulation of the co-stimulatory axis of CCR2 by MCP-1 is essentially required for mast cell-mediated hypersensitivity reactions in mouse eyes.

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