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Bleomycin inhibits hepatic mixed function oxidation.

Authors
  • Montgomery, M R
  • Furry, J
  • Fernandez, S
Type
Published Article
Journal
Research communications in chemical pathology and pharmacology
Publication Date
Nov 01, 1981
Volume
34
Issue
2
Pages
287–293
Identifiers
PMID: 6175013
Source
Medline
License
Unknown

Abstract

Bleomycin inhibits hepatic microsomal ethylmorphine N-demethylase activity in both the athymic (nude) mouse and the rat four days after a single injection. This inhibition occurred both with subcutaneous and intraperitoneal injections. With multiple dose chronic treatment, s.c. injections resulted in decreases in both enzymatic activity and cytochrome P450 concentration in both species. However, i.p. chronic injection resulted in decreases only in the rat.

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