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Blastic Plasmacytoid Dendritic Cell Neoplasm: How do You Distinguish It from Acute Myeloid Leukemia?

Authors
  • Reichard, Kaaren K1
  • 1 Division of Hematopathology, Mayo Clinic, 200 1st Street Southwest, Hilton Building 8th Floor, Rochester, MN 55902, USA. Electronic address: [email protected]
Type
Published Article
Journal
Surgical pathology clinics
Publication Date
Dec 01, 2013
Volume
6
Issue
4
Pages
743–765
Identifiers
DOI: 10.1016/j.path.2013.08.010
PMID: 26839196
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

BPDCN is a recently elucidated clinicopathologic entity. This disease typically involves the skin, with 30% to 40% of patients showing an additional concurrent leukemic component. Although BPDCN often exhibits cytologic features akin to acute lymphoblastic leukemia, the main differential diagnostic challenge, in the skin and in the bone marrow, is distinction from AML, in particular AML with monocytic differentiation. Copyright © 2013 Elsevier Inc. All rights reserved.

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