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Black titania-based theranostic nanoplatform for single NIR laser induced dual-modal imaging-guided PTT/PDT.

Authors
  • Mou, Juan1
  • Lin, Tianquan2
  • Huang, Fuqiang2
  • Chen, Hangrong3
  • Shi, Jianlin4
  • 1 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. , (China)
  • 2 CAS Key Laboratory of Materials for Energy Conversion, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. , (China)
  • 3 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: [email protected] , (China)
  • 4 State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, PR China. Electronic address: [email protected] , (China)
Type
Published Article
Journal
Biomaterials
Publication Date
Apr 01, 2016
Volume
84
Pages
13–24
Identifiers
DOI: 10.1016/j.biomaterials.2016.01.009
PMID: 26803408
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Substantially different from traditional combinatorial-treatment of photothermal therapy (PTT) and photodynamic therapy (PDT) by using multi-component nanocomposite under excitation of separate wavelength, a novel single near infrared (NIR) laser-induced multifunctional theranostic nanoplatform has been rationally and successfully constructed by a single component black titania (B-TiO2-x) for effective imaging-guided cancer therapy for the first time. This multifunctional PEGylated B-TiO2-x shows high dispersity/stability in aqueous solution, excellent hemo/histocompatibility and broad absorption ranging from NIR to ultraviolet (UV). Both in vitro and in vivo results well demonstrated that such a novel multifunctional theranostic nanoplaform could achieve high therapeutic efficacy of simultaneous and synergistic PTT/PDT under the guidance of infrared thermal/photoacoustic (PA) dual-modal imaging, which was triggered by a single NIR laser. This research circumvents the conventional obstacles of using multi-component nanocomposites, UV light and high laser power density. Furthermore, negligible side effects to blood and main tissues could be found in 3 months' investigation, facilitating its potential biomedical application. Copyright © 2016 Elsevier Ltd. All rights reserved.

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