Affordable Access

deepdyve-link
Publisher Website

In Black Africans with rheumatoid arthritis, ACPA recognize citrullinated fibrinogen and the derived peptides α36-50Cit38,42 and β60-74Cit60,72,74, like in Caucasians

Authors
  • Nogueira, Leonor
  • Cornillet, Martin
  • Singwe-Ngandeu, Madeleine
  • Viatte, Sebastien
  • Bas, Sylvette
  • Gabay, Cem
  • Serre, Guy1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 8
  • 1 “Epidermis Differentiation and Rheumatoid Autoimmunity” Laboratory
  • 2 UMR CNRS 5165
  • 3 INSERM U1056
  • 4 Toulouse III University
  • 5 Laboratory of Cell Biology and Cytology
  • 6 Toulouse University Hospital
  • 7 Unit of Rheumatology
  • 8 School of Medicine
  • 9 University of Yaounde I
  • 10 Arthritis Research UK Center for Genetics and Genomics, Centre for Musculoskeletal Research, Manchester Academic Health Science Centre
  • 11 The University of Manchester
  • 12 Division of Rheumatology
  • 13 University Hospitals of Geneva
  • 14 Department of Genetics and Laboratory Medicine
  • 15 Department of Pathology & Immunology
  • 16 University of Geneva
Type
Published Article
Journal
Clinical Immunology
Publisher
Elsevier BV
Publication Date
Jan 01, 2014
Accepted Date
Feb 17, 2014
Volume
152
Issue
1-2
Pages
58–64
Identifiers
DOI: 10.1016/j.jaut.2011.07.003
Source
Elsevier
Keywords
License
Unknown

Abstract

•Autoantibodies to citrullinated fibrin are good markers for RA in Black Africans.•Their fine specificities (anti-α36-50 or β60-74) are similar to those of Caucasians.•Like in Caucasians, the two specificities summarize 93% of the reactivity of ACPA.•HLA-DRB1 SE alleles are associated with higher titres of autoantibodies.•ACPA features are similar irrespective of genetic and environmental backgrounds.

Report this publication

Statistics

Seen <100 times