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Bit1 in anoikis resistance and tumor metastasis

Authors
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Jun 28, 2013
Volume
333
Issue
2
Pages
147–151
Identifiers
DOI: 10.1016/j.canlet.2013.01.043
Source
Ruoslahti Lab
License
Green

Abstract

Epithelial cells and most adherent normal cells rely on adhesion-dependent, integrin-mediated survival signals from the extracellular matrix (ECM) to survive. When these cells are deprived of adhesion to the ECM, they undergo a specific form of apoptosis termed "anoikis." In contrast, malignant cells have attained mechanisms to enable them to survive in the absence of adhesion and are considered anchorage-independent. This review will focus on the biological function of the Bcl2-inhibitor of transcription (Bit1) protein in the anoikis process, the underlying molecular mechanism of Bit1 apoptotic function, and its role in tumor metastasis.

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