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[Bisphosphonates in oncology].

Authors
Type
Published Article
Journal
Der Orthopäde
Publication Date
Volume
36
Issue
2
Pages
131–135
Identifiers
PMID: 17252255
Source
Medline
License
Unknown

Abstract

Since bone metastases occur as a result of hematogenous spreading of tumor cells, therapy with curative intent is no longer feasible and palliative options for treating and preventing skeletal events are essential. Today, bisphosphonates are established in the systemic treatment of bone metastases. This report provides an overview of molecular mechanisms of action and clinical data of bisphosphonates in patients with skeletal metastases of breast and prostate cancer as the most common solid tumors which spread to the bone.

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