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[Bisphosphonates-associated osteonecrosis of the jaw: review on reported cases].

Authors
  • Gering, Audrey
  • Grange, Laurent
  • Villier, Céline
  • Woeller, Anne
  • Mallaret, Michel
Type
Published Article
Journal
Thérapie
Publication Date
Jan 01, 2007
Volume
62
Issue
1
Pages
49–54
Identifiers
PMID: 17374348
Source
Medline
License
Unknown

Abstract

Osteonecrosis of the jaws associated with the use of bisphosphonates (alendronate, pamidronate, risedronate et zoledronate) are described as an avascular necrosis. We have listed 184 cases of bisphosphonates-associated osteonecrosis of the maxillary in the literature. Many mechanisms are discussed in bisphosphonates-associated osteonecrosis: a disturbing bone turnover, an accumulation of bone's microdamage or an antiangiogenic effect. Other risk factors seem however to be involved: cancer, chemotherapy, glucocorticoids, infection and renal insufficiency.

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