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Bispecific Antibodies: An Innovative Arsenal to Hunt, Grab and Destroy Cancer Cells

Authors
Type
Published Article
Journal
Current Topics in Medicinal Chemistry
Publisher
Bentham Science
Publication Date
Jun 05, 2015
Volume
16
Issue
8
Identifiers
DOI: 10.2174/1389201016666150505124037
Source
LBMCC
Keywords
License
Yellow

Abstract

Targeted cellular immunotherapy with bifunctional antibodies (bsAbs) has emerged as a promising therapeutic approach for cancer over the last two decades. Progress in antibody engineering has led to the generation of many different types of antibody-derived entities that display at least two binding specificities. Most bsAbs consist of large IgG-like proteins with multiple antigen-binding regions containing Fc parts or smaller entities without Fc. BsAbs have the potential to engage effector cells of the immune system, thereby …

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