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[Biphenyl derivatives as by-products from the synthesis of 4-aryl-4H-pyrans].

Authors
  • Görlitzer, K
  • Trittmacher, J
  • Jones, P G
Type
Published Article
Journal
Die Pharmazie
Publication Date
Jul 01, 2005
Volume
60
Issue
7
Pages
494–497
Identifiers
PMID: 16076073
Source
Medline
License
Unknown

Abstract

The reaction of the 1,5-diketones 1 with acetic anhydride/acetic acid in the presence of zinc chloride yields the 4-aryl-4H-pyrans 2 as main products. The annulated lactone 3 and the cyclohexene derivatives 5 are isolated as by-products. The configuration of the cyclohexanone 4a and the cyclohexenes 5 are deduced from nmr spectroscopic methods. The structure of 5b is confirmed by X-ray crystal analysis.

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