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The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats.

Authors
  • Başkaya, M K
  • Rao, A M
  • Doğan, A
  • Donaldson, D
  • Dempsey, R J
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Apr 18, 1997
Volume
226
Issue
1
Pages
33–36
Identifiers
PMID: 9153635
Source
Medline
License
Unknown

Abstract

This study examined the time course of the blood-brain barrier (BBB) opening and correlated this with brain edema formation after a lateral controlled cortical impact (CCI) brain injury in rats. Quantitative measurement of Evans blue (EB) extravasation using fluorescence was employed at 2, 4, 6 h and 1, 2, 3, 4 and 7 days after injury. Brain edema was measured by specific gravity of the tissue at corresponding time points. Two prominent EB extravasations were observed at 4-6 h and 3-day after injury in the injury-site cortex and the ipsilateral hippocampus. Brain edema became progressively more severe over time and peaked at 24 h after injury and began to decline after day 3. These results suggest that there is a biphasic opening of the BBB after CCI brain injury and the second opening of the BBB does not contribute to a further increase in edema formation.

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