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The biphasic mystery: why a biphasic shock is more effective than a monophasic shock for defibrillation.

Authors
Type
Published Article
Journal
Journal of theoretical biology
Publication Date
Volume
200
Issue
1
Pages
1–17
Identifiers
PMID: 10479536
Source
Medline
License
Unknown

Abstract

We demonstrate that a biphasic shock is more effective than a monophasic shock at eliminating reentrant electrical activity in an ionic model of cardiac ventricular electrical activity. This effectiveness results from early hyperpolarization that enhances the recovery of sodium inactivation, thereby enabling earlier activation of recovering cells. The effect can be seen easily in a model of a single cell and also in a cable model with a ring of excitable cells. Finally, we demonstrate the phenomenon in a two-dimensional model of cardiac tissue.

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