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Biotransformation of 4beta-hydroxyeudesmane-1,6-dione by Gliocladium roseum and Exserohilum halodes.

Authors
  • García-Granados, A
  • Gutiérrez, M C
  • Rivas, F
  • Arias, J M
Type
Published Article
Journal
Phytochemistry
Publisher
Elsevier
Publication Date
Nov 01, 2001
Volume
58
Issue
6
Pages
891–895
Identifiers
PMID: 11684186
Source
Medline
License
Unknown

Abstract

Biotransformation of sesquiterpene 4beta-hydroxyeudesmane-1,6-dione by the filamentous fungi Gliocladium roseum and Exserohilum halodes was achieved. With Exserohilum halodes, only one metabolite was obtained, as a result of the regio- and stereoselective reduction of the keto group at C-1, which is difficult to achieve by chemical means. Five metabolites were produced with Gliocladium roseum, three of which, the 7alpha-hydroxylated, the 7alpha,11- and the 1alpha,8alpha-dihydroxylated derivatives, have not previously been reported. The hydroxylation at C-11 is the main action of this microorganism. These 11-hydroxylated compounds can be chemically transformed into 6beta,12-eudesmanolides.

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