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Biotinylation of histones in human cells. Effects of cell proliferation.

Authors
Type
Published Article
Journal
European journal of biochemistry / FEBS
Publication Date
Volume
268
Issue
20
Pages
5424–5429
Identifiers
PMID: 11606205
Source
Medline

Abstract

An enzymatic mechanism has been proposed by which biotinidase may catalyze biotinylation of histones. Here, human cells were found to covalently bind biotin to histones H1, H2A, H2B, H3, and H4. Cells respond to proliferation with increased biotinylation of histones; biotinylation increases early in the cell cycle and remains increased during the cycle. Notwithstanding the catalytic role of biotinidase in biotinylation of histones, mRNA encoding biotinidase and biotinidase activity did not parallel the increased biotinylation of histones in proliferating cells. Biotinylation of histones might be regulated by enzymes other than biotinidase or by the rate of histone debiotinylation.

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