Affordable Access

deepdyve-link
Publisher Website

Biotechnological production of enantiopure epoxides by enzymatic kinetic resolution.

Authors
  • Choi, Won Jae
Type
Published Article
Journal
Applied Microbiology and Biotechnology
Publisher
Springer-Verlag
Publication Date
Aug 01, 2009
Volume
84
Issue
2
Pages
239–247
Identifiers
DOI: 10.1007/s00253-009-2110-9
PMID: 19590868
Source
Medline
License
Unknown

Abstract

Enantiopure epoxides are high value-added synthons for the production of pharmaceuticals, agrochemicals, as well as versatile fine chemicals and have broad scope of market demand for their applications. A major challenge in conventional organic synthesis is to generate such compounds in high enantiopurity with reasonable yield. Among possible chemical and biological technologies for enantiopure epoxide preparation, enzymatic kinetic resolution has been paid much attention with respect to its high enantioselectivity. Epoxide hydrolase (EH) has shown promising characteristics for the preparation of enantiopure epoxides and vicinal diols during enantioselective hydrolysis of racemic epoxides. EH is readily available from microbial resources thus it is being employed for biohydrolysis of a variety of epoxides. Recent technical progress in EH-catalyzed enantioselective hydrolysis is summarized in terms of exploration of novel EH, its functional improvement, high throughput assay, and preparative scale resolution process.

Report this publication

Statistics

Seen <100 times