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Biosynthesis: a sulfonate relay revealed.

Authors
Type
Published Article
Journal
Nature Chemical Biology
1552-4450
Publisher
Nature Publishing Group
Publication Date
Volume
9
Issue
10
Pages
602–603
Identifiers
DOI: 10.1038/nchembio.1319
PMID: 23912166
Source
Medline

Abstract

Biological sulfonate incorporation is mediated by 3′-phosphoadenosine-5′-phosphosulfate-dependent sulfotransferases and, to a lesser extent, arylsulfate sulfotransferases. An unusual two-enzyme strategy for sulfonate mobilization involving both types of sulfotransferases has been revealed during antibiotic biosynthesis, which uses a new polyketide as the sulfonate shuttle.

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