Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.
- Published Article
Science (New York, N.Y.)
- Publication Date
Jan 22, 1982
A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/7199205