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Biosynthesis and processing of a human precursor complement protein, pro-C3, in a hepatoma-derived cell line.

Authors
  • Morris, K M
  • Goldberger, G
  • Colten, H R
  • Aden, D P
  • Knowles, B B
Type
Published Article
Journal
Science (New York, N.Y.)
Publication Date
Jan 22, 1982
Volume
215
Issue
4531
Pages
399–400
Identifiers
PMID: 7199205
Source
Medline
License
Unknown

Abstract

A 180,000-dalton single-chain molecule (human pro-C3) is the precursor of the third component of human complement (C3), a disulfide-linked two-chain protein. The pro-C3 is converted by limited proteolysis to C3. The relationship between pro-C3 and C3 was established with the use of Hep G2, a cell line derived from a human hepatocellular carcinoma, which synthesizes at least 17 plasma proteins.

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