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[Bioreactors in regenerative medicine--from a technical device to a reconstructive alternative?].

Authors
  • Polykandriotis, E
  • Schmidt, V J
  • Kneser, U
  • Jianming, S
  • Boccaccini, A R
  • Horch, R E
Type
Published Article
Journal
Handchirurgie, Mikrochirurgie, plastische Chirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Handchirurgie : Organ der Deutschsprachigen Arbeitsgemeinschaft für Mikrochirurgie der Peripheren Nerven und Gefässe : Organ der Vereinigung der Deutschen Plastischen Chirurgen
Publication Date
Aug 01, 2012
Volume
44
Issue
4
Pages
198–203
Identifiers
DOI: 10.1055/s-0032-1321838
PMID: 22932852
Source
Medline
License
Unknown

Abstract

With the advent of the era of tissue engineering (TE), experimental settings have been developed that allow for a defined environment with optimised cell growth conditions and/or the production of specific substitutes. These isolated systems have been termed "bioreactors". By translating the principles of bioreactors into an in vivo context, advances in biomaterial sciences and cell biology have been merged into an integrative research concept. Even today, in the age of regenerative Medicine (RegMed) the transfer of experimental in vitro findings into a clinical in vivo approach still remains a vast challenge. In order to fulfil these specific requirements bioreactors had to be defined anew. Latest advances in areas like reconstructive medicine (the arteriovenous loop as a means of organogenesis) or modern wound management (topical negative pressure therapy as a perfusion bioreactor) give new impulses towards the translation of Reg-Med concepts into the clinical routine.

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