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Bio-prospecting endemic Mascarene Aloes for potential neuroprotectants.

Authors
  • Lobine, D1, 2
  • Howes, M-J R3
  • Cummins, I2
  • Govinden-Soulange, J1
  • Ranghoo-Sanmukhiya, M1
  • Lindsey, K2
  • Chazot, P L2
  • 1 Faculty of Agriculture, University of Mauritius, Réduit, Mauritius. , (Mauritius)
  • 2 School of Biological & Biomedical Sciences, Durham University, Durham, UK.
  • 3 Natural Capital and Plant Health Department, Jodrell Laboratory, Royal Botanic Gardens, Kew, Richmond, Surrey, UK.
Type
Published Article
Journal
Phytotherapy Research
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 11, 2017
Identifiers
DOI: 10.1002/ptr.5941
PMID: 29024309
Source
Medline
Keywords
License
Unknown

Abstract

The Mascarene Aloes are used in the traditional pharmacopoeia against various ailments including cutaneous diseases and as antispasmodics. Scientific evidence to support these claims is non-existent and mainly based on the scientific repute of A. vera. The antioxidant profile of methanolic leaf extracts of A. purpurea Lam., A. tormentorii (Marais) L. E. Newton & G. D. Rowley, A. lomatophylloides Balf. f., A. macra Haw. and A. vera (L.) Burm. f. was studied using the total antioxidant capacity, copper equivalent and superoxide dismutase assays. In vitro cytotoxicity was evaluated on CAD (Cath.-a-differentiated) neuronal cells by the methyl tetrazolium assay, and the neuroprotective profile was assessed using hydrogen peroxide-induced neurotoxicity with the CAD cells. The aloin and vitexin content were determined by high-performance liquid chromatography with diode-array detection. A. purpurea had the highest aloin content (546.6 nmol/g), while A. tormentorii had the highest vitexin content (67.3 nmol/g). A. macra (concentration <0.1 mg/mL) elicited a 10% cytotoxicity effect on CAD cells while other Mascarene Aloes were not cytotoxic. This study validates the antioxidant and neuroprotective potential of Mascarene Aloes focusing on their aloin and vitexin content that are also present in other reputed medicinal Aloes.

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