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Bioprinting of skin constructs for wound healing

Authors
  • He, Peng1
  • Zhao, Junning2
  • Zhang, Jiumeng3, 4
  • Li, Bo3, 4
  • Gou, Zhiyuan3, 4
  • Gou, Maling3, 4
  • Li, Xiaolu1, 2
  • 1 The Affiliated Hospital of Southwest Medical University, the department of Plastic & Burns Surgery, Tai Ping Street, Luzhou, 646000, People’s Republic of China , Luzhou (China)
  • 2 Sichuan Academy of Chinese Medical Sciences, Sichuan Translational Medicine Center of Chinese Medicine, Ren Min Nan Lu Road, Chengdu, 610041, People’s Republic of China , Chengdu (China)
  • 3 Sichuan University, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Chengdu, 610041, People’s Republic of China , Chengdu (China)
  • 4 Collaborative Innovation Center for Biotherapy, Chengdu, 610041, People’s Republic of China , Chengdu (China)
Type
Published Article
Journal
Burns & Trauma
Publisher
BioMed Central
Publication Date
Jan 23, 2018
Volume
6
Issue
1
Identifiers
DOI: 10.1186/s41038-017-0104-x
Source
Springer Nature
Keywords
License
Green

Abstract

Extensive burns and full-thickness skin wounds are difficult to repair. Autologous split-thickness skin graft (ASSG) is still used as the gold standard in the clinic. However, the shortage of donor skin tissues is a serious problem. A potential solution to this problem is to fabricate skin constructs using biomaterial scaffolds with or without cells. Bioprinting is being applied to address the need for skin tissues suitable for transplantation, and can lead to the development of skin equivalents for wound healing therapy. Here, we summarize strategies of bioprinting and review current advances of bioprinting of skin constructs. There will be challenges on the way of 3D bioprinting for skin regeneration, but we still believe bioprinting will be potential skills for wounds healing in the foreseeable future.

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