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Bioprinting and Biofabrication with Peptide and Protein Biomaterials.

Authors
  • Boyd-Moss, Mitchell1, 2
  • Fox, Kate1
  • Brandt, Milan1, 3
  • Nisbet, David4
  • Williams, Richard5, 6
  • 1 School of Engineering, RMIT University, Melbourne, VIC, Australia. , (Australia)
  • 2 Biofab3D, St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia. , (Australia)
  • 3 Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne, VIC, Australia. , (Australia)
  • 4 Laboratory of Advanced Biomaterials, Research School of Engineering, The Australian National University, Canberra, ACT, Australia. , (Australia)
  • 5 School of Engineering, RMIT University, Melbourne, VIC, Australia. [email protected] , (Australia)
  • 6 Biofab3D, St. Vincent's Hospital Melbourne, Fitzroy, VIC, Australia. [email protected] , (Australia)
Type
Published Article
Journal
Advances in experimental medicine and biology
Publication Date
Jan 01, 2017
Volume
1030
Pages
95–129
Identifiers
DOI: 10.1007/978-3-319-66095-0_5
PMID: 29081051
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The ability to fabricate artificial tissue constructs through the controlled organisation of cells, structures and signals within a biomimetic scaffold offers significant promise to the field of regenerative medicine, drug delivery and tissue engineering. Advances in additive manufacturing technologies have facilitated the printing of spatially defined cell-laden artificial tissue constructs capable of providing biomimetic spatiotemporal presentation of biological and physical cues to cells in a designed multicomponent structure. Despite significant progress in the field of bioprinting, a key challenge remains in developing and utilizing materials that can adequately recapitulate the complexities of the native extracellular matrix on a nanostructured, chemical level during the printing process. This gives rise to the need for suitable materials - particularly in establishing effective control over cell fate, tissue vascularization and innervation. Recently, significant interested has been invested into developing candidate materials using protein and peptide-derived biomaterials. The ability of these materials to form highly printable hydrogels which are reminiscent of the native ECM has seen significant use in a variety of regenative applications, including both organ bioprinting and non-organ bioprinting. Here, we discuss the emerging technologies for peptide-based bioprinting applications, highlighting bioink development and detailing bioprinter processors. Furthermore, this work presents application specific, peptide-based bioprinting approaches, and provides insight into current limitations and future perspectives of peptide-based bioprinting techniques.

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