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Biophysical Insights into the Inhibitory Mechanism of Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors.

Authors
  • Schauer, Grant
  • Leuba, Sanford
  • Sluis-Cremer, Nicolas
Type
Published Article
Journal
Biomolecules
Publication Date
Jan 01, 2013
Volume
3
Issue
4
Pages
889–904
Identifiers
DOI: 10.3390/biom3040889
PMID: 24970195
Source
Medline
License
Unknown

Abstract

HIV-1 reverse transcriptase (RT) plays a central role in HIV infection. Current United States Federal Drug Administration (USFDA)-approved antiretroviral therapies can include one of five approved non-nucleoside RT inhibitors (NNRTIs), which are potent inhibitors of RT activity. Despite their crucial clinical role in treating and preventing HIV-1 infection, their mechanism of action remains elusive. In this review, we introduce RT and highlight major advances from experimental and computational biophysical experiments toward an understanding of RT function and the inhibitory mechanism(s) of NNRTIs.

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