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Biophysical characterization of bladder cancer cells with different metastatic potential.

Authors
  • Liu, Haijiao
  • Tan, Qingyuan
  • Geddie, William R
  • Jewett, Michael A S
  • Phillips, Nigel
  • Ke, Danbing
  • Simmons, Craig A
  • Sun, Yu
Type
Published Article
Journal
Cell Biochemistry and Biophysics
Publisher
Springer-Verlag
Publication Date
Mar 01, 2014
Volume
68
Issue
2
Pages
241–246
Identifiers
DOI: 10.1007/s12013-013-9702-9
PMID: 23793959
Source
Medline
License
Unknown

Abstract

Specific membrane capacitance (SMC) and Young's modulus are two important parameters characterizing the biophysical properties of a cell. In this work, the SMC and Young's modulus of two cell lines, RT4 and T24, corresponding to well differentiated (low grade) and poorly differentiated (high grade) urothelial cell carcinoma (UCC), respectively, were quantified using microfluidic and AFM measurements. Quantitative differences in SMC and Young's modulus values of the high-grade and low-grade UCC cells are, for the first time, reported.

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