Biopharmaceutical studies on crude drug preparations. I: Permeation of paeonol in a decoction and dry extract of Paeonia suffruticosa root cortex using an absorption simulator.
- Published Article
Journal of Ethnopharmacology
- Publication Date
Jan 01, 1987
The permeation behavior of paeonol, one active constituent of a crude Chinese drug called Moutan Cortex, through an artificial gastric lipid barrier was examined in vitro using an absorption simulator in order to clarify how the administered form influenced the bioavailability of paeonol from a crude preparation. Paeonol concentrations were determined by a high-performance liquid chromatographic method developed during this study. Paeonol showed greater permeation from artificial gastric juice into artificial plasma when it was applied as a decoction or freeze-dried extract of Moutan Cortex than when applied as purified paeonol alone.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/3695554