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Biomolecular condensates in membrane receptor signaling.

Authors
  • Jaqaman, Khuloud1
  • Ditlev, Jonathon A2
  • 1 Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA; Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Electronic address: [email protected]
  • 2 Program in Molecular Medicine, Hospital for Sick Children, Toronto, ON, M5G 0A4, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, M5S 1A8, Canada. Electronic address: [email protected] , (Canada)
Type
Published Article
Journal
Current opinion in cell biology
Publication Date
Jan 15, 2021
Volume
69
Pages
48–54
Identifiers
DOI: 10.1016/j.ceb.2020.12.006
PMID: 33461072
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Clustering is a prominent feature of receptors at the plasma membrane (PM). It plays an important role in signaling. Liquid-liquid phase separation (LLPS) of proteins is emerging as a novel mechanism underlying the observed clustering. Receptors/transmembrane signaling proteins can be core components essential for LLPS (such as LAT or nephrin) or clients enriched at the phase-separated condensates (for example, at the postsynaptic density or at tight junctions). Condensate formation has been shown to regulate signaling in multiple ways, including by increasing protein binding avidity and by modulating the local biochemical environment. In moving forward, it is important to study protein LLPS at the PM of living cells, its interplay with other factors underlying receptor clustering, and its signaling and functional consequences. Copyright © 2020 Elsevier Ltd. All rights reserved.

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