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Biomolecular condensates in autophagy regulation.

Authors
  • Fujioka, Yuko1
  • Noda, Nobuo N2
  • 1 Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan. , (Japan)
  • 2 Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan. Electronic address: [email protected] , (Japan)
Type
Published Article
Journal
Current opinion in cell biology
Publication Date
Jan 11, 2021
Volume
69
Pages
23–29
Identifiers
DOI: 10.1016/j.ceb.2020.12.011
PMID: 33445149
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Autophagy is an intracellular degradation system that contributes to cellular homeostasis. Autophagosome formation is a landmark event in autophagy, which sequesters and delivers cytoplasmic components to the lysosome for degradation. Based on selectivity, autophagy can be classified into bulk and selective autophagy, which are mechanistically distinct from each other, especially in the requirement of cargos for autophagosome formation. Recent studies revealed that liquid-like biomolecular condensates, which are formed through liquid-liquid phase separation, regulate the autophagosome formation of both bulk and selective autophagy. Here, we focus on recent findings on the involvement of biomolecular condensates in autophagy regulation and discuss their significance. Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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