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Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis.

Authors
  • Schweitzer, Mary H
  • Zheng, Wenxia
  • Organ, Chris L
  • Avci, Recep
  • Suo, Zhiyong
  • Freimark, Lisa M
  • Lebleu, Valerie S
  • Duncan, Michael B
  • Vander Heiden, Matthew G
  • Neveu, John M
  • Lane, William S
  • Cottrell, John S
  • Horner, John R
  • Cantley, Lewis C
  • Kalluri, Raghu
  • Asara, John M
Type
Published Article
Journal
Science
Publisher
American Association for the Advancement of Science (AAAS)
Publication Date
May 01, 2009
Volume
324
Issue
5927
Pages
626–631
Identifiers
DOI: 10.1126/science.1165069
PMID: 19407199
Source
Medline
License
Unknown

Abstract

Molecular preservation in non-avian dinosaurs is controversial. We present multiple lines of evidence that endogenous proteinaceous material is preserved in bone fragments and soft tissues from an 80-million-year-old Campanian hadrosaur, Brachylophosaurus canadensis [Museum of the Rockies (MOR) 2598]. Microstructural and immunological data are consistent with preservation of multiple bone matrix and vessel proteins, and phylogenetic analyses of Brachylophosaurus collagen sequenced by mass spectrometry robustly support the bird-dinosaur clade, consistent with an endogenous source for these collagen peptides. These data complement earlier results from Tyrannosaurus rex (MOR 1125) and confirm that molecular preservation in Cretaceous dinosaurs is not a unique event.

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