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Biomarkers of toluene exposure in rats: mercapturic acids versus traditional indicators (urinary hippuric acid and o-cresol and blood toluene).

Authors
  • Cosnier, Frédéric
  • Cossec, Benoît
  • Burgart, Manuella
  • Nunge, Hervé
  • Brochard, Céline
  • Décret, Marie-Josèphe
  • Rémy, Aurélie
Type
Published Article
Journal
Xenobiotica; the fate of foreign compounds in biological systems
Publication Date
Aug 01, 2013
Volume
43
Issue
8
Pages
651–660
Identifiers
DOI: 10.3109/00498254.2012.754114
PMID: 23278281
Source
Medline
License
Unknown

Abstract

1. Toluene (TOL) is a neurotoxic, ototoxic and reprotoxic solvent which is metabolized via the glutathione pathway, producing benzylmercapturic, o-, m- and p-toluylmercapturic acids (MAs). These metabolites could be useful as biomarkers of TOL exposure. 2. The aims of this study were (1) to provide data on MAs excretion in rat urine following TOL exposure by inhalation, (2) to compare them to data from traditional TOL biomarkers, i.e. TOL in blood (Tol-B), and urinary hippuric acid (HA) and o-cresol (oCre) and (3) to establish a relationship between these different indicators and the airborne TOL concentration (Tol-A). 3. Sprague-Dawley rats were exposed to a range of TOL concentrations. Blood and urine were collected and analyzed to determine biomarker levels. 4. Levels of the four MAs correlate strongly with Tol-A (comparable to the correlation with Tol-B). 5. MAs are thus clearly superior to oCre and HA as potential markers of exposure to TOL.

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