Affordable Access

Access to the full text

Biomarkers of intake for tropical fruits

  • Vázquez-Manjarrez, N.1, 2, 3
  • Ulaszewska, M.4
  • Garcia-Aloy, M.5, 6
  • Mattivi, F.4, 7
  • Praticò, G.2
  • Dragsted, L. O.2
  • Manach, C.1
  • 1 Université Clermont Auvergne, INRAE, Clermont-Ferrand, F-63000, France , Clermont-Ferrand (France)
  • 2 University of Copenhagen, Copenhagen, Denmark , Copenhagen (Denmark)
  • 3 Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico , Mexico City (Mexico)
  • 4 Fondazione Edmund Mach, Via Mach 1, San Michele all’Adige, 38010, Italy , San Michele all’Adige (Italy)
  • 5 University of Barcelona, Barcelona, Spain , Barcelona (Spain)
  • 6 CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Barcelona, Spain , Barcelona (Spain)
  • 7 University of Trento, San Michele all’Adige, Italy , San Michele all’Adige (Italy)
Published Article
Genes & Nutrition
Publication Date
Jun 19, 2020
DOI: 10.1186/s12263-020-00670-4
Springer Nature


Consumption of fruit and vegetable is a key component of a healthy and sustainable diet. However, their accurate dietary assessment remains a challenge. Due to errors in self-reporting methods, the available dietary information is usually biased. Biomarkers of intake constitute objective tools to better reflect the usual or recent consumption of different foods, including fruits and vegetables. Partners of The Food Biomarker Alliance (FoodBall) Project have undertaken the task of reviewing the available literature on putative biomarkers of tropical fruit intake. The identified candidate biomarkers were subject to validation evaluation using eight biological and chemical criteria. This publication presents the current knowledge on intake biomarkers for 17 tropical fruits including banana, mango, and avocado as the most widely consumed ones. Candidate biomarkers were found only for banana, avocado, and watermelon. An array of banana-derived metabolites has been reported in human biofluids, among which 5-hydroxyindole-acetic acid, dopamine sulfate, methoxyeugenol glucuronide, salsolinol sulfate, 6-hydroxy-1-methyl-1,2,3,4-tetrahydro-β-carboline-sulfate, and other catecholamine metabolites. Their validation is still at an early stage, with insufficient data on dose-response relationship. Perseitol and mannoheptulose have recently been reported as candidate biomarkers for avocado intake, while the amino acid citrulline has been associated with watermelon intake. Additionally, the examination of food composition data revealed some highly specific phytochemicals, which metabolites after absorption may be further studied as putative BFI for one or several tropical fruits. To make the field move forward, untargeted metabolomics, as a data-driven explorative approach, will have to be applied in both intervention and observational studies to discover putative BFIs, while their full validation and the establishment of dose-response calibration curves will require quantification methods at a later stage.

Report this publication


Seen <100 times