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Biomarkers of Alzheimer's disease in body fluids.

Authors
  • Zheng, YanPeng
  • He, JinSheng
  • Hong, Tao
Type
Published Article
Journal
Science China. Life sciences
Publication Date
Apr 01, 2010
Volume
53
Issue
4
Pages
490–496
Identifiers
DOI: 10.1007/s11427-010-0081-9
PMID: 20596916
Source
Medline
License
Unknown

Abstract

Various innovative diagnostic methods for Alzheimer's disease (AD) have been developed in view of the increasing prevalence and consequences of later-life dementia. Biomarkers in cerebrospinal fluid (CSF) and blood for AD are primarily based on the detection of components derived from amyloid plaques and neurofibrillary tangles (NFTs). Published reports on CSF and blood biomarkers in AD indicate that although biomarkers in body fluids may be utilized in the clinical diagnosis of AD, there are no specific markers that permit accurate and reliable diagnosis of early-stage AD or the monitoring of disease progression.

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