Affordable Access

deepdyve-link
Publisher Website

Bio-manufacture of human platelets for transfusion: rationale and approaches

Authors
  • Lee, Eun-ju
  • Godara, Pankaj
  • Haylock, David1, 2, 3, 4
  • 1 Materials Science and Engineering
  • 2 Commonwealth Scientific Industrial Research Organisation
  • 3 Australian Regenerative Medicine Institute
  • 4 Monash University
Type
Published Article
Journal
Experimental Hematology
Publisher
Elsevier
Publication Date
Jan 01, 2014
Accepted Date
Feb 10, 2014
Identifiers
DOI: 10.1016/j.exphem.2014.02.002
Source
Elsevier
License
Unknown

Abstract

Platelets for transfusion, obtained from volunteer blood donors are a limited resource. Given the increased range of donor restrictions to prevent transmission of disease and the decline in volunteer blood donors there is a diminishing pool of blood for transfusion. Production of mature blood cells from hematopoietic stem cells (HSCs) via large-scale manufacture is an alternative way of meeting transfusion demands. In this review we provide a detailed outline of the challenges and opportunities for the bio-manufacture of platelets. We describe the scale required for platelet bio-manufacture to deliver sufficient cells for transfusion, a brief outline of the current understanding of megakaryopoiesis and thrombogenesis and highlight how this impacts on the design of culture systems and bioreactors for producing platelets.

Report this publication

Statistics

Seen <100 times