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The Biology of Myxofibrosarcoma: State of the Art and Future Perspectives

Authors
  • Sambri, Andrea
  • De Paolis, Massimiliano
  • Spinnato, Paolo
  • Donati, Davide Maria
  • Bianchi, Giuseppe
Type
Published Article
Journal
Oncology Research and Treatment
Publisher
S. Karger GmbH
Publication Date
May 25, 2020
Volume
43
Issue
6
Pages
314–322
Identifiers
DOI: 10.1159/000507334
PMID: 32450554
Source
Karger
Keywords
License
Green
External links

Abstract

Background: Myxofibrosarcoma (MFS) is among the most highly complex sarcoma types. Molecular cytogenetic studies have identified a high level of genomic complexity. Summary: This review provides an update of the current research related to MFS, with particular emphasis on emerging mechanisms of tumorigenesis and their potential therapeutic impact. Many novel possible molecular markers have been identified, not only for prognostication in MFS, but also to serve as possible therapeutic targets, and thereby improve clinical outcomes. However, the molecular pathogenesis of MFS remains incompletely understood. Key Messages: Patients suffering from advanced MFS might benefit from expanded molecular evaluation in order to detect specific expression profiles and identify drug-able targets. Moreover, immunotherapy represents an intriguingly perspective due to the presence of “T-cell inflamed” tumor microenvironment.

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