Affordable Access

Biology and clinical aspects of the hematopoietic growth factors.

Authors
  • Sieff, C A1
  • 1 Division of Hematology and Oncology, Dana Farber Cancer Institute, Boston, Massachusetts.
Type
Published Article
Journal
Annual review of medicine
Publication Date
1990
Volume
41
Pages
483–496
Identifiers
PMID: 2184746
Source
Medline
License
Unknown

Abstract

Molecular cloning of the genes for several members of a family of glycoproteins, the hematopoietic growth factors (HGFs), has transformed experimental hematology. Molecular probes have been used to investigate the cellular source of the HGFs and the mechanism by which their genes are regulated. Recombinant purified HGFs have been used to investigate their functions in vitro, the binding characteristics of their receptors, and the isolation of certain receptor cDNAs. This increase in knowledge of the cellular biology of the HGFs has led to clinical trials of their efficacy. Specific HGFs or HGF combinations are likely to find a place in the management of several different bone marrow failure states.

Report this publication

Statistics

Seen <100 times