Affordable Access

deepdyve-link
Publisher Website

BIOLOGICS: TARGET-SPECIFIC TREATMENT OF SYSTEMIC AND CUTANEOUS AUTOIMMUNE DISEASES

Journal
Indian Journal of Dermatology
Publisher
Medknow Publications
Publication Date
Jan 01, 2009
Volume
54
Issue
2
Identifiers
DOI: 10.4103/0019-5154.53175
Keywords
Disciplines
  • Biology
  • Design
  • Medicine
License
Unknown

Abstract

Biologics are becoming important in the treatment of systemic and cutaneous autoimmune diseases. They are designed to target specific components of immune system. As the new drugs are capable of targeting proteins in a more specific fashion, yet have lower risks of systemic side-effects, they have considerable advantages over the older immunomodulators. The development of TNF-alpha blockers in the treatment of psoriasis, psoriatic arthritis, rheumatoid arthritis, Crohn's disease and ankylosing spondylitis have been major breakthroughs. Likewise, B-cell depletion has proved to be equally revolutionary for the treatment of lupus, pemphigus, certain vasculitides etc. But all said and done, the development of these molecules and their clinical usage are still at evolving stages. Consensus needs be formed to further categorize the clinical profiles of the patients in whom biologics are to be used in the future, given that the long-term safety profiles of these agents are very much unknown at present.

Report this publication

Statistics

Seen <100 times