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The biological response to orthopaedic implants for joint replacement: Part I: Metals

Authors
  • Gibon, Emmanuel
  • Amanatullah, Derek F.
  • Loi, Florence
  • Pajarinen, Jukka
  • Nabeshima, Akira
  • Yao, Zhenyu
  • Moussa Hamadouche
  • Goodman, Stuart B.
Type
Published Article
Journal
Journal of Biomedical Materials Research Part B: Applied Biomaterials
Publisher
Wiley
Publication Date
Jul 13, 2016
Volume
105
Issue
7
Pages
2162–2173
Identifiers
DOI: 10.1002/jbm.b.33734
PMID: 27328111
PMCID: PMC5537059
Source
USPC - SET - SVS
License
Green

Abstract

Joint replacement is a commonly performed, highly successful orthopaedic procedure, for which surgeons have a large choice of different materials and implant designs. The materials used for joint replacement must be both biologically acceptable to minimize adverse local tissue reactions, and robust enough to support weight bearing during common activities of daily living. Modern joint replacements are made from metals and their alloys, polymers, ceramics, and composites. This review focuses on the biological response to the different biomaterials used for joint replacement. In general, modern materials for joint replacement are well tolerated by the body as long as they are in bulk (rather than in particulate or ionic) form, are mechanically stable and noninfected. If the latter conditions are not met, the prosthesis will be associated with an acute/chronic inflammatory reaction, peri-prosthetic osteolysis, loosening and failure. This article (Part 1 of 2) is dedicated to the use of metallic devices in orthopaedic surgery including the associated biological response to metallic byproducts is a review of the basic science literature regarding this topic. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2162-2173, 2017.

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