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Biological Relevance of Free Radicals and Nitroxides

Authors
  • Prescott, Christopher1
  • Bottle, Steven E.1
  • 1 Queensland University of Technology, Brisbane, Australia , Brisbane (Australia)
Type
Published Article
Journal
Cell Biochemistry and Biophysics
Publisher
Springer-Verlag
Publication Date
Oct 06, 2016
Volume
75
Issue
2
Pages
227–240
Identifiers
DOI: 10.1007/s12013-016-0759-0
Source
Springer Nature
Keywords
License
Yellow

Abstract

Nitroxides are stable, kinetically-persistent free radicals which have been successfully used in the study and intervention of oxidative stress, a critical issue pertaining to cellular health which results from an imbalance in the levels of damaging free radicals and redox-active species in the cellular environment. This review gives an overview of some of the biological processes that produce radicals and other reactive oxygen species with relevance to oxidative stress, and then discusses interactions of nitroxides with these species in terms of the use of nitroxides as redox-sensitive probes and redox-active therapeutic agents

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