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Biological properties of dihydro-leukotriene B4, an alternative leukotriene B4 metabolite.

Authors
  • Kaever, V
  • Damerau, B
  • Wessel, K
  • Resch, K
Type
Published Article
Journal
FEBS Letters
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 25, 1988
Volume
231
Issue
2
Pages
385–388
Identifiers
PMID: 2834233
Source
Medline
License
Unknown

Abstract

Dihydro-leukotriene B4 (a 5,12-dihydroxy-eicosatrienoic acid) has been shown to be the primary metabolite of leukotriene B4 (LTB4) in a variety of cells other than human polymorphonuclear leukocytes (PMNLs). In this report we show that dihydro-LTB4 is significantly less active than LTB4 in different biological assay systems, i.e. leukocyte chemotaxis, chemokinesis, aggregation, adhesion to endothelium and superoxide anion production. This suggests that primary reduction constitutes a second so far unknown deactivation pathway for LTB4.

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