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Biological properties of a CD4 immunoadhesin.

Authors
  • Byrn, R A
  • Mordenti, J
  • Lucas, C
  • Smith, D
  • Marsters, S A
  • Johnson, J S
  • Cossum, P
  • Chamow, S M
  • Wurm, F M
  • Gregory, T
  • Groopman, J E
  • Capon, D J
Type
Published Article
Journal
Nature
Publication Date
Apr 12, 1990
Volume
344
Issue
6267
Pages
667–670
Identifiers
PMID: 1970124
Source
Medline
License
Unknown

Abstract

Molecular fusions of CD4, the receptor for human immunodeficiency virus (HIV), with immunoglobulin (termed CD4 immunoadhesins) possess both the gp120-binding and HIV-blocking properties of recombinant soluble CD4, and certain properties of IgG, notably long plasma half-life and Fc receptor binding. Here we show that a CD4 immunoadhesin can mediate antibody-dependent cell-mediated cytotoxicity (ADCC) towards HIV-infected cells, although, unlike natural anti-gp120 antibodies, it does not allow ADCC towards uninfected CD4-expressing cells that have bound soluble gp120 to the CD4 on their surface. In addition, CD4 immunoadhesin, like natural IgG molecules, is efficiently transferred across the placenta of a primate. These observations have implications for the therapeutic application of CD4 immunoadhesins, particularly in the area of perinatal transmission of HIV infection.

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