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Biological functions and research progress of eIF4E

Authors
  • Chen, Xiaocong1
  • An, Yang1
  • Tan, Mengsi1
  • Xie, Dongrui1
  • Liu, Ling2, 3, 4
  • Xu, Benjin2, 3, 4
  • 1 Department of Clinical Medicine, Fenyang College of Shanxi Medical University, Fenyang , (China)
  • 2 Department of Medical Laboratory Science, Fenyang College of Shanxi Medical University, Fenyang , (China)
  • 3 Key Laboratory of Lvliang for Clinical Molecular Diagnostics, Fenyang , (China)
  • 4 Department of Clinical Laboratory, Fenyang Hospital of Shanxi Province, Fenyang , (China)
Type
Published Article
Journal
Frontiers in Oncology
Publisher
Frontiers Media SA
Publication Date
Aug 03, 2023
Volume
13
Identifiers
DOI: 10.3389/fonc.2023.1076855
Source
Frontiers
Keywords
Disciplines
  • Oncology
  • Review
License
Green

Abstract

The eukaryotic translation initiation factor eIF4E can specifically bind to the cap structure of an mRNA 5' end, mainly regulating translation initiation and preferentially enhancing the translation of carcinogenesis related mRNAs. The expression of eIF4E is closely related to a variety of malignant tumors. In tumor cells, eIF4E activity is abnormally increased, which stimulates cell growth, metastasis and translation of related proteins. The main factors affecting eIF4E activity include intranuclear regulation, phosphorylation of 4EBPs, and phosphorylation and sumoylation of eIF4E. In this review, we summarize the biological functions and the research progress of eIF4E, the main influencing factors of eIF4E activity, and the recent progress of drugs targeting eIF4E, in the hope of providing new insights for the treatment of multiple malignancies and development of targeted drugs.

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