Affordable Access

Biological effects and equivalent doses in radiotherapy: a software solution

Authors
  • Voyant, Cyril
  • Julian, Daniel
  • Roustit, Rudy
  • Biffi, Katia
  • Marcovici, Celine Lantieri
Type
Published Article
Publication Date
Aug 23, 2013
Submission Date
Aug 23, 2013
Identifiers
arXiv ID: 1308.5906
Source
arXiv
License
Yellow
External links

Abstract

The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. We therefore propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to the equivalent dose computed using standard calculators in seven French radiotherapy centers.

Report this publication

Statistics

Seen <100 times