Affordable Access

Biological effect of the Planktothrix sp. FP1 cyanobacterial extract.

Authors
  • Prati, M
  • Molteni, M
  • Pomati, F
  • Rossetti, C
  • Bernardini, G
Type
Published Article
Journal
Toxicon
Publisher
Elsevier
Publication Date
Mar 01, 2002
Volume
40
Issue
3
Pages
267–272
Identifiers
PMID: 11711123
Source
Medline
License
Unknown

Abstract

Cyanobacteria are common and potentially harmful inhabitants of freshwater and marine environments worldwide. Some waterbloom-forming cyanobacteria are toxic and they may cause animal death and adversely affect human health. A filamentous freshwater cyanobacterium, Planktothrix sp. FP1, was found to be responsible for a toxic algal bloom in Lake Varese (Italy) during August of 1997. In the present study, the biological effects of the Planktothrix sp. FP1 cell extract on Xenopus embryos and on human Peripheral Blood Mononuclear Cells (PBMC) were investigated. FETAX (Frog Embryo Teratogenesis Assay-Xenopus) showed that the cyanobacterial extract had no teratogenic potential, though embryotoxicity was detected (LC(50) 2.944g/l wet weight). The same extract inhibited the proliferation of PBMC stimulated in vitro by phytohemagglutinin (PHA), and strongly interfered with the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma).

Report this publication

Statistics

Seen <100 times