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Bioinspired Nanoemulsions Stabilized by Phosphoethanolamine and Phosphoglycerol Lipids

Authors
  • Caianiello, Carlo1
  • D’Avino, Marcellino1
  • Cavasso, Domenico1
  • Paduano, Luigi1, 2
  • D’Errico, Gerardino1, 2
  • 1 (L.P.)
  • 2 CSGI, Consorzio Interuniversitario per lo Sviluppo dei Sistemi a Grande Interfase, Via della Lastruccia 3, I-50019 Sesto Fiorentino, Florence, Italy
Type
Published Article
Journal
Nanomaterials
Publisher
MDPI AG
Publication Date
Jun 18, 2020
Volume
10
Issue
6
Identifiers
DOI: 10.3390/nano10061185
PMID: 32570696
PMCID: PMC7353300
Source
PubMed Central
Keywords
License
Green

Abstract

Water-in-oil (W/O) nanoemulsions stabilized by phospholipids (PLs) are increasingly exploited in a wide spectrum of applications, from pharmaceuticals to food and cosmetic formulations. In this work, we report the design and optimization of an innovative emulsion based on a mixture of phosphoethanolamine (PE) and phosphoglycerol (PG) PLs, inspired by the composition of the inner leaflet of a bacterial outer membrane. Using the natural oil squalene as the continuous organic phase, no additional emulsion stabilizer is needed. On the other hand, a small amount of Span 80 is required when dodecane is used. The obtained nanoemulsions are stable for at least two hours, thus allowing the droplet size and distribution to be characterized by Dynamic Light Scattering (DLS) and the lipid layer structure and dynamics to be analyzed by Electron Paramagnetic Resonance (EPR) spectroscopy. The results indicate that squalene shallowly intercalates among the lipid tail termini, being unable to deeply penetrate the adsorbed lipid monolayer. The altered lipid dynamics are proposed to be the reason for the enhanced emulsion stability, this paving the way to future implementations and possible applications.

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