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Biodegradable amphipathic peptide hydrogels as extended-release system for opioid peptides

Authors
  • Martin, Charlotte
  • Dumitrascuta, Maria
  • Mannes, Morgane
  • Lantero, Aquilino
  • Bucher, Dominik
  • Walker, Katja
  • Van Wanseele, Yannick
  • Oyen, Edith
  • Hernot, Sophie
  • Van Eeckhaut, Ann
  • Madder, Annemieke
  • Hoogenboom, Richard
  • Spetea, Mariana
  • Ballet, Steven
Publication Date
Jan 01, 2018
Source
Ghent University Institutional Archive
Keywords
Language
English
License
Unknown
External links

Abstract

Chronic pain is currently treated with opioids that offer unsatisfactory long-term analgesia and produce serious side effects. There is a clear need for alternative therapies. Herein, peptide-based hydrogels are used as extended-release drug delivery carriers. Two different formulations were developed: the drug is coformulated within the hydrogen the drug is an integral part of the hydrogelator. Both strategies afford a prolonged and significant antinociception up to 72 h after subcutaneous administration in mice.

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