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Biocompatible polyhydroxyalkanoates/bacterial cellulose composites: Preparation, characterization, and in vitro evaluation.

Authors
  • Chiulan, Ioana1
  • Mihaela Panaitescu, Denis1
  • Nicoleta Frone, Adriana1
  • Teodorescu, Mircea2
  • Andi Nicolae, Cristian1
  • Căşărică, Angela3
  • Tofan, Vlad4
  • Sălăgeanu, Aurora4
  • 1 Department of Polymer, National Institute for R&D in Chemistry and Petrochemistry ICECHIM, Bucharest, Romania. , (Oman)
  • 2 Department of Bioresources and Polymer Science, Faculty of Applied Chemistry and Materials Science, Polytechnic University of Bucharest, Bucharest, Romania. , (Oman)
  • 3 Department of Pharmaceutical Biotechnologies, National Institute for Chemical Pharmaceutical R&D ICCF, Bucharest, Romania. , (Oman)
  • 4 Infection and Immunity Laboratory, Cantacuzino National Institute, Bucharest, Romania. , (Oman)
Type
Published Article
Journal
Journal of Biomedical Materials Research Part A
Publisher
Wiley (John Wiley & Sons)
Publication Date
Oct 01, 2016
Volume
104
Issue
10
Pages
2576–2584
Identifiers
DOI: 10.1002/jbm.a.35800
PMID: 27242044
Source
Medline
Keywords
License
Unknown

Abstract

Biocompatible composites play a critical role as scaffolds in tissue engineering. Novel biocomposites made from poly(3-hydroxybutyrate) (PHB), polyhydroxyalkanoate (PHA) and bacterial cellulose (BC) in different concentrations were prepared by solution casting and their thermal and mechanical behavior as well as biocompatibility was characterized. BC addition increased the thermal stability of the polymer matrix as evidenced by thermogravimetric analysis. The crystallinity of PHB and the crystallization temperature decreased with the addition of BC and PHA, thus increasing the processing window. BC in small concentration determined an increase in the mechanical properties due to a concerted action of PHA and filler. Good cells attachment and proliferation were observed for all the biocomposites. By the addition of PHA (more hydrophobic than the matrix) and various amounts of BC (highly hydrophilic), surface properties and cell attachment can be controlled. Cytocompatibility studies using L929 cell line revealed that this material is suitable for biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2576-2584, 2016.

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