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Biocompatibility of particles of GORE-TEX cruciate ligament prosthesis: an investigation both in vitro and in vivo.

Authors
  • Thomson, L A1
  • Law, F C
  • James, K H
  • Rushton, N
  • 1 University of Cambridge Orthopaedic Research Unit, Addenbrooke's Hospital, UK.
Type
Published Article
Journal
Biomaterials
Publisher
Elsevier
Publication Date
Oct 01, 1991
Volume
12
Issue
8
Pages
781–785
Identifiers
PMID: 1799654
Source
Medline
License
Unknown

Abstract

This research was to determine the biocompatibility of simulated wear particles from a GORE-TEX cruciate ligament prosthesis using in vitro and in vivo techniques. Exposure of normal human synovial fibroblasts and primary mouse peritoneal macrophages to the particles revealed no cytotoxicity, as determined by lactate dehydrogenase release, but beta-N-acetyl-D-glucosaminidase was released from macrophages at high concentrations, showing inflammatory potential. This was not seen when the particles were injected into mouse knees, where no adverse reactions were observed. These simulated wear particles were shown to be biocompatible using these in vitro and in vivo systems.

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