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Biocompatibility and bioactivity of porous polymer-derived Ca-Mg silicate ceramics.

Authors
  • Fiocco, L1
  • Li, S2
  • Stevens, M M3
  • Bernardo, E1
  • Jones, J R4
  • 1 Dipartimento di Ingegneria Industriale, University of Padova, Via Marzolo, 9, 35131 Padova, Italy. , (Italy)
  • 2 Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • 3 Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK; Institute of Biomedical Engineering, Imperial College London, South Kensington Campus, SW7 2AZ London, UK; Department of Bioengineering, Imperial College London, South Kensington Campus, SW7 2AZ London, UK.
  • 4 Department of Materials, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Electronic address: [email protected]
Type
Published Article
Journal
Acta biomaterialia
Publication Date
Mar 01, 2017
Volume
50
Pages
56–67
Identifiers
DOI: 10.1016/j.actbio.2016.12.043
PMID: 28017870
Source
Medline
Keywords
License
Unknown

Abstract

Here, we show that the incorporation of Mg in Ca-silicates plays a significant role in the enhancement of the osteogenic differentiation and matrix formation of MC3T3-E1 cells, cultured on polymer-derived highly porous scaffolds. Reduced degradation rates and improved mechanical properties are also observed, compared to Mg-free counterparts, suggesting the great potential of Ca-Mg silicates as bone tissue engineering materials. Excellent biocompatibility of the new materials, in accordance to the ISO10993-5 and ISO10993-12 standard guidelines, confirms the preceramic polymer route as an efficient synthesis methodology for bone scaffolds. The use of hydrated fillers as porogens is an additional novelty feature presented in the manuscript.

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